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ea0056oc8.3 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

Circulating levels of microRNAs associate with blood pressure and left ventricular mass in primary hypertensive patients

van Kralingen J.C. , Larsen C.K. , Connell J.M. , Freel E.M. , Zennaro M.C. , MacKenzie S.M. , Davies E.

Introduction: MicroRNA (miRNA) has been shown to post-transcriptionally regulate physiological systems modulating blood pressure, including the adrenal biosynthesis of aldosterone. This raises the possibility that levels of specific miRNAs circulating in plasma might reflect these functional effects and have diagnostic value in the identification of hypertension and its various underlying causes. In a previous study, we measured plasma levels of miRNAs originating from the miR...

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ea0011oc44 | Endocrine genetics | ECE2006

Functional impact of polymorphic variation in the gene encoding 11β-hydroxylase (CYP11B1): reduced adrenal 11-hydroxylase efficiency identifies a key intermediate phenotype in hypertension

Barr M , Friel E , MacKenzie SM , Holloway CD , Freel EM , Brain NJR , Wilkinson DM , Ingram M , Fraser R , Dominiczak AF , Connell JMC , Davies E

The regulation of aldosterone secretion is altered in essential hypertension: the phenotype of relative aldosterone excess is present in up to 15% of subjects. The gene encoding aldosterone synthase (CYP11B2) offers an obvious candidate to account for this and a polymorphism in its 5′ untranslated region (UTR; −344C/T) is associated with increased frequency of hypertension and higher aldosterone levels. However, this variation is more closely associated with...

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Endocrine Abstracts

Circulating levels of microRNAs associate with blood pressure and left ventricular mass in primary hypertensive patients

Functional impact of polymorphic variation in the gene encoding 11β-hydroxylase (CYP11B1): reduced adrenal 11-hydroxylase efficiency identifies a key intermediate phenotype in hypertension

BiosciAbstracts